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Coronary disease causes one-third of all deaths in the developed world.The knowledge that low-density lipoprotein (LDL) causes coronary disease led to devel-
Investigation of the mechanisms by which plant metabolism is altered in response to pathogens, particularly with respect to phytoalexin synthesis and accumulation, is an area of plant biochemistry that is actively being explored. Host-parasite interactions between C. lindemuthianum and bean, particularly those involved in systemic induced resistance, provide challenging subjects for this type of research.
In conclusion, it appears that pisatih-inducing compounds are not unique to plant, pathogenic fungi. We have recently observed that foreign cells, such as pollen grains and mouse tumor cells, effectively induce pisatin synthesis in pea tissue. It is likely that phytoalexin production is a type of incompatibility response initiated by any of a diverse group of compounds which are released by fungal pathogens and other foreign cell types when intimately associated with pea tissues. In general, the more unrelated cell types incite a more intense response than the closely related cell types. The mode by which the diverse cell types induce pisatin may be variable, but the response is consistently dependent on transcription of new genetic message.The message needed for maximal pisatin production could be associated with a segment of chromatin which becomes readily accessible to RNA polymerase following a variety of changes in DNA conformation. Since there are numerous ways to alter DNA conformation, one might also expect that induction could be initiated by a chemically diverse group of compounds.
Photosynthesis, both natural and as a model process, is examined as a possible annually renewable resource for both material and energy. The conversion of carbohydrate from cane, beets and other sources through fermentation alcohol to hydrocarbon may soon again become economic in the light of increasing costs of recovery of hydrocarbon from fossil sources and improved fermentation technology. Even the direct photosynthetic production of hydrocarbon from known sources (Hevea, etc.) or newly bred ones seems possible.Finally, more distantly, synthetic systems constructed on the basis of growing knowledge of the photosynthetic processes, may produce both fuel and power.