In times when resilience in social and economic, geopolitical, green, and digital dimensions was introduced as an official compass for EU policymakers (EC, 2020a), the concept of resilience as the ability to withstand and cope with endogenous as well as exogenous challenges while undergoing transitions in a sustainable, fair, and democratic manner, secured its prominence in the EU policymaking. The COVID-19 pandemic has undoubtedly unfolded the EU’s need to enhance its resilience. This becomes especially important for the EU’s southern and eastern periphery as well, arguably the most fragile parts of the EU. The ambition of this monograph was thus to fill the gap in the literature, which tends to overlook the EU’s peripheral countries in the east and south in terms of their resilience building against the abrupt nonlinear changes erupting in one system (e.g., climate) but having impacts beyond the system’s boundaries (e.g., society, economy, and politics). In order to analyze the resilience of the peripheral EU countries, we employed an interdisciplinary approach, combining theoretical intersections from the social tipping point literature, public policy, regional economic resilience, and European studies. This allowed us to shed light on two, still relatively understudied areas in the resilience literature – social tipping points and EU peripheral studies – and present a conceptual framework of governance of tipping points in the EU periphery. The conceptual framework links together the concepts of social tipping points, governance, state capacity, state resilience, and interactions between the state and non-state actors. Moreover, the multilevel governance approach is also complemented with a coherent description of the structural factors contributing to lower levels of resilience to the detriment of the EU periphery in the east and south. Subsequently, the conceptual framework is tested against three case studies, each social tipping point with a different trigger (migration, climate change, and geopolitics) and each social tipping point situated in a different EU peripheral country (Greece, Slovakia, and Poland). Such a multiple case study research design ensures greater robustness and validity of the results.