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In a chronic inflammatory disease as rheumatoid arthritis, the local processes in the affected tissues lead to destruction of the joint. When estimating the inflammatory activity in rheumatic joint diseases, a major problem is the rather unspecific and indirect character of the biochemical and the crude character of the clinical measures used.
In order to secure the mechanical integrity of the skeleton bone undergoes constant renewal throughout life. This renewal process, bone remodeling, consists of the continuos removal of bone (bone resorption) followed by synthesis of new bone matrix and subsequent mineralization (bone formation). Bone remodeling is also an integral part of the calcium homeostatic system together with the kidneys and the gut.